USP10 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: ubiquitin specific peptidase 10
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight:
Uniprot: Q14694
Gene id: 9100
Background: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53
TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53
TP53 stability: in unstressed cells, specifically deubiquitinates p53
TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53
TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53
TP53, leading to regulate the p53
TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53
TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3
VPS34-containing complexes. In turn, PIK3C3
VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3
VPS34-containing complexes regulate p53
TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage(PubMed:25861989).
Field of research: Epigenetics, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, IF
Dilution: IHC: 1:50-1:200; IF: 1:20-1:100
Target: USP10
Purification: Immunogen affinity purified
Reactivity: Human, Mouse
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: ubiquitin specific peptidase 10
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight:
Uniprot: Q14694
Gene id: 9100
Background: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53
TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53
TP53 stability: in unstressed cells, specifically deubiquitinates p53
TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53
TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53
TP53, leading to regulate the p53
TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53
TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3
VPS34-containing complexes. In turn, PIK3C3
VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3
VPS34-containing complexes regulate p53
TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage(PubMed:25861989).
Field of research: Epigenetics, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, IF
Dilution: IHC: 1:50-1:200; IF: 1:20-1:100
Target: USP10
Purification: Immunogen affinity purified
Reactivity: Human, Mouse