TNFSF11 antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 4F11
Isotype: IgG1
Immunogen: tumor necrosis factor (ligand) superfamily, member 11
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 35 kDa
Uniprot: O14788
Gene id: 8600
Background: TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL induces osteoclast formation through its receptor, RANK, which transduces signals by recruiting adaptor molecules, such as the TNF receptor-associated factor (TRAF) family of proteins. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. RANKL was shown to activate antiapoptotic kinase AKT
PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
Field of research: Immunology, Signal Transduction, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:1000-1:5000
Target: TNFSF11
Purification: Protein A+G purification
Reactivity: Human
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Clonality: Monoclonal
Clone: 4F11
Isotype: IgG1
Immunogen: tumor necrosis factor (ligand) superfamily, member 11
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 35 kDa
Uniprot: O14788
Gene id: 8600
Background: TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL induces osteoclast formation through its receptor, RANK, which transduces signals by recruiting adaptor molecules, such as the TNF receptor-associated factor (TRAF) family of proteins. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. RANKL was shown to activate antiapoptotic kinase AKT
PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
Field of research: Immunology, Signal Transduction, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:1000-1:5000
Target: TNFSF11
Purification: Protein A+G purification
Reactivity: Human