ZYX antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 8D5
Isotype: IgG1
Immunogen: zyxin
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 80 kDa
Uniprot: Q15942
Gene id: 7791
Background: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin(ZYX) is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles.
Field of research: Cell Division and Proliferation, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200
Target: ZYX
Purification: Protein A+G purification
Reactivity: Human, Mouse
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Clonality: Monoclonal
Clone: 8D5
Isotype: IgG1
Immunogen: zyxin
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 80 kDa
Uniprot: Q15942
Gene id: 7791
Background: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin(ZYX) is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles.
Field of research: Cell Division and Proliferation, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200
Target: ZYX
Purification: Protein A+G purification
Reactivity: Human, Mouse