USP5 antibody - 100 µg

Host : Mouse
Clonality: Monoclonal
Clone: 6G1
Isotype: IgG1
Immunogen: ubiquitin specific peptidase 5(isopeptidase T)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 93 kDa
Uniprot: P45974
Gene id: 8078
Background: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53
TP53 and an increase in p53
TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53
TP53 but not with MDM2 for proteasomal recognition.
Field of research: Epigenetics, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:5000
Target: USP5
Purification: Protein A+G purification
Reactivity: Human