USP44 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: ubiquitin specific peptidase 44
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 81 kDa
Uniprot: Q9H0E7
Gene id: 84101
Background: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex
cyclosome(APC
C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC
C ternary complex(also named mitotic checkpoint complex), thereby preventing premature activation of the APC
C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B(H2BK120ub1) ubiquitination.
Field of research: Epigenetics, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:5000
Target: USP44
Purification: Immunogen affinity purified
Reactivity: Human
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: ubiquitin specific peptidase 44
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 81 kDa
Uniprot: Q9H0E7
Gene id: 84101
Background: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex
cyclosome(APC
C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC
C ternary complex(also named mitotic checkpoint complex), thereby preventing premature activation of the APC
C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B(H2BK120ub1) ubiquitination.
Field of research: Epigenetics, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:5000
Target: USP44
Purification: Immunogen affinity purified
Reactivity: Human