USP13 antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 9E6
Isotype: IgG1
Immunogen: ubiquitin specific peptidase 13(isopeptidase T-3)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 97 kDa
Uniprot: Q92995
Gene id: 8975
Background: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation(ERAD). Component of a regulatory loop that controls autophagy and p53
TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3
VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53
TP53 stability. In turn, PIK3C3
VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3
VPS34-containing complexes regulate p53
TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation(ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
Field of research: Epigenetics, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200
Target: USP13
Purification: Protein A+G purification
Reactivity: Human
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Clonality: Monoclonal
Clone: 9E6
Isotype: IgG1
Immunogen: ubiquitin specific peptidase 13(isopeptidase T-3)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 97 kDa
Uniprot: Q92995
Gene id: 8975
Background: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation(ERAD). Component of a regulatory loop that controls autophagy and p53
TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3
VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53
TP53 stability. In turn, PIK3C3
VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3
VPS34-containing complexes regulate p53
TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation(ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
Field of research: Epigenetics, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200
Target: USP13
Purification: Protein A+G purification
Reactivity: Human