TRPV6 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: transient receptor potential cation channel, subfamily V, member 6
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 82 kDa, 70 kDa
Uniprot: Q9H1D0
Gene id: 55503
Background: Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine(PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin(By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification(PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
Field of research: Cancer
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IF, WB, IP
Dilution: WB: 1:500-1:5000; IP: 1:200-1:1000; IF: 1:10-1:100
Target: TRPV6
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: transient receptor potential cation channel, subfamily V, member 6
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 82 kDa, 70 kDa
Uniprot: Q9H1D0
Gene id: 55503
Background: Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine(PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin(By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification(PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
Field of research: Cancer
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IF, WB, IP
Dilution: WB: 1:500-1:5000; IP: 1:200-1:1000; IF: 1:10-1:100
Target: TRPV6
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat