TNIP2 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: TNFAIP3 interacting protein 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 50 kDa
Uniprot: Q8NFZ5
Gene id: 79155
Background: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO
IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK
ERK signaling pathway during innate immune response; this function seems to be stimulus-and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Field of research: Cardiovascular, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IF, IHC
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Target: TNIP2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: TNFAIP3 interacting protein 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 50 kDa
Uniprot: Q8NFZ5
Gene id: 79155
Background: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO
IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK
ERK signaling pathway during innate immune response; this function seems to be stimulus-and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Field of research: Cardiovascular, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IF, IHC
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Target: TNIP2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat