TERF2 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: telomeric repeat binding factor 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 65-69 kDa
Uniprot: Q15554
Gene id: 7014
Background: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP
RAP1 and DCLRE1B
Apollo. Component of the shelterin complex(telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B
Apollo, plays a key role in telomeric loop(T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B
Apollo to telomeres and activate the exonuclease activity of DCLRE1B
Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B
Apollo, required to control the amount of DNA topoisomerase(TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP
RAP1 to telomeres, thereby participating in to repressing homology-directed repair(HDR), which can affect telomere length.
Field of research: Cell Division and Proliferation, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: TERF2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: telomeric repeat binding factor 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 65-69 kDa
Uniprot: Q15554
Gene id: 7014
Background: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP
RAP1 and DCLRE1B
Apollo. Component of the shelterin complex(telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B
Apollo, plays a key role in telomeric loop(T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B
Apollo to telomeres and activate the exonuclease activity of DCLRE1B
Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B
Apollo, required to control the amount of DNA topoisomerase(TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP
RAP1 to telomeres, thereby participating in to repressing homology-directed repair(HDR), which can affect telomere length.
Field of research: Cell Division and Proliferation, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: TERF2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse