TCHP antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: trichoplein, keratin filament binding
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 61 kDa
Uniprot: Q9BT92
Gene id: 84260
Background: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8
K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells(PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis(PubMed:25270598).
Field of research: Cancer
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: TCHP
Purification: Immunogen affinity purified
Reactivity: Human
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: trichoplein, keratin filament binding
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 61 kDa
Uniprot: Q9BT92
Gene id: 84260
Background: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8
K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells(PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis(PubMed:25270598).
Field of research: Cancer
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: TCHP
Purification: Immunogen affinity purified
Reactivity: Human