SESN1 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: sestrin 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 66-68 kDa
Uniprot: Q9Y6P5
Gene id: 27244
Background: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway(PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses(By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1(PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein(By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1(PubMed:15105503). However, this could not be confirmed(By similarity).
Field of research: Cardiovascular
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: SESN1
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: sestrin 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 66-68 kDa
Uniprot: Q9Y6P5
Gene id: 27244
Background: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway(PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses(By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1(PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein(By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1(PubMed:15105503). However, this could not be confirmed(By similarity).
Field of research: Cardiovascular
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: SESN1
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat