RIPK2 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: receptor-interacting serine-threonine kinase 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 46-55 kDa, 61-72 kDa
Uniprot: O43353
Gene id: 8767
Background: Serine
threonine
tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7
TAK1 to IKBKG
NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG
NEMO and subsequent activation of IKBKB
IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor(TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
Field of research: Immunology, Signal Transduction, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: RIPK2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: receptor-interacting serine-threonine kinase 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 46-55 kDa, 61-72 kDa
Uniprot: O43353
Gene id: 8767
Background: Serine
threonine
tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7
TAK1 to IKBKG
NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG
NEMO and subsequent activation of IKBKB
IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor(TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
Field of research: Immunology, Signal Transduction, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: RIPK2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat