RIPK3 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: receptor-interacting serine-threonine kinase 3
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 57 kDa
Uniprot: Q9Y572
Gene id:
Background: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Field of research: Signal Transduction, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IP, WB,IHC
Dilution: WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:100-1:400
Target: RIPK3
Purification: Immunogen affinity purified
Reactivity: Human, Mouse
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: receptor-interacting serine-threonine kinase 3
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 57 kDa
Uniprot: Q9Y572
Gene id:
Background: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Field of research: Signal Transduction, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IP, WB,IHC
Dilution: WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:100-1:400
Target: RIPK3
Purification: Immunogen affinity purified
Reactivity: Human, Mouse