RGMA antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: RGM domain family, member A
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 49 kDa
Uniprot: Q96B86
Gene id: 56963
Background: Member of the repulsive guidance molecule(RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1
neogenin induces activation of RHOA-ROCK1
Rho-kinase signaling pathway through UNC5B-ARHGEF12
LARG-PTK2
FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1
neogenin leads to HRAS inactivation by influencing HRAS-PTK2
FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein(BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Field of research: Neuroscience
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IP
Dilution: WB: 1:500-1:2000; IP: 1:200-1:2000
Target: RGMA
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
![]()
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: RGM domain family, member A
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 49 kDa
Uniprot: Q96B86
Gene id: 56963
Background: Member of the repulsive guidance molecule(RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1
neogenin induces activation of RHOA-ROCK1
Rho-kinase signaling pathway through UNC5B-ARHGEF12
LARG-PTK2
FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1
neogenin leads to HRAS inactivation by influencing HRAS-PTK2
FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein(BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Field of research: Neuroscience
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IP
Dilution: WB: 1:500-1:2000; IP: 1:200-1:2000
Target: RGMA
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat