RFWD3 antibody - 100 µg

Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: ring finger and WD repeat domain 3
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 85 kDa
Uniprot: Q6PCD5
Gene id: 55159
Background: E3 ubiquitin-protein ligase that mediates the ubiquitination of p53
TP53 in the late response to DNA damage, and acts as a positive regulator of p53
TP53 stability, thereby regulating the G1
S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53
TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53
TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53
TP53. Plays a role in RPA-mediated DNA damage signaling and repair.
Field of research: Epigenetics, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Target: RFWD3
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat