RBBP6 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: retinoblastoma binding protein 6
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 200 kDa
Uniprot: Q7Z6E9
Gene id: 5930
Background: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome(PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53
TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53
TP53; may function as negative regulator of p53
TP53, leading to both apoptosis and cell growth(By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites(CFSs) in a ZBTB38-and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication(PubMed:24726359).
Field of research: Epigenetics, Immunology, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: RBBP6
Purification: Immunogen affinity purified
Reactivity: Human, Mouse
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: retinoblastoma binding protein 6
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 200 kDa
Uniprot: Q7Z6E9
Gene id: 5930
Background: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome(PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53
TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53
TP53; may function as negative regulator of p53
TP53, leading to both apoptosis and cell growth(By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites(CFSs) in a ZBTB38-and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication(PubMed:24726359).
Field of research: Epigenetics, Immunology, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: RBBP6
Purification: Immunogen affinity purified
Reactivity: Human, Mouse