RACGAP1 antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 1B5
Isotype: IgG1
Immunogen: Rac GTPase activating protein 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 71 kDa
Uniprot: Q9H0H5
Gene id: 29127
Background: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP(GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.
Field of research: Signal Transduction, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:20-1:100
Target: RACGAP1
Purification: Protein A+G purification
Reactivity: Human, Mouse, Rat
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Clonality: Monoclonal
Clone: 1B5
Isotype: IgG1
Immunogen: Rac GTPase activating protein 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 71 kDa
Uniprot: Q9H0H5
Gene id: 29127
Background: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP(GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.
Field of research: Signal Transduction, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:20-1:100
Target: RACGAP1
Purification: Protein A+G purification
Reactivity: Human, Mouse, Rat