PTPN22 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: protein tyrosine phosphatase, non-receptor type 22(lymphoid)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 79-95 kDa
Uniprot: Q9Y2R2
Gene id: 26191
Background: Acts as negative regulator of T-cell receptor(TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz
CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules(PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue(PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue(PubMed:16461343). Dephosphorylates the immune system activator SKAP2(PubMed:21719704). Positively regulates toll-like receptor(TLR)-induced type 1 interferon production(PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon(By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy(PubMed:23991106).
Field of research: Signal Transduction, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IP
Dilution: WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Target: PTPN22
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: protein tyrosine phosphatase, non-receptor type 22(lymphoid)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 79-95 kDa
Uniprot: Q9Y2R2
Gene id: 26191
Background: Acts as negative regulator of T-cell receptor(TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz
CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules(PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue(PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue(PubMed:16461343). Dephosphorylates the immune system activator SKAP2(PubMed:21719704). Positively regulates toll-like receptor(TLR)-induced type 1 interferon production(PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon(By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy(PubMed:23991106).
Field of research: Signal Transduction, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IP
Dilution: WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Target: PTPN22
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat