TTR antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 8E4
Isotype: IgG1
Immunogen: transthyretin
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 16 kDa
Uniprot: P02766
Gene id: 7276
Background: Transthyretin(TTR) is a plasma transport protein for thyroxine and retinol, through the association with retinol-binding protein. It is a homotetrameric protein synthesized mainly in liver, choroid plexus, retinal pigment epithelium, and pancreas.Within the CNS, TTR is the only known protein synthesized solely by the choroid plexus. Mutant and wildtype TTR give rise to various forms of amyloid deposition(amyloidosis). Defects in TTR are the cause of amyloidosis transthyretin-related(AMYL-TTR),hyperthyroxinemia dystransthyretinemic euthyroidal(HTDE) and carpal tunnel syndrome type 1(CTS1). In addition, positive immunostaining for TTR has been reported as a sensitive diagnostic marker of choroid plexus tumors.(22103483)
Field of research: Cancer, Immunology, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200
Target: TTR
Purification: Protein A+G purification
Reactivity: Human
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Clonality: Monoclonal
Clone: 8E4
Isotype: IgG1
Immunogen: transthyretin
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 16 kDa
Uniprot: P02766
Gene id: 7276
Background: Transthyretin(TTR) is a plasma transport protein for thyroxine and retinol, through the association with retinol-binding protein. It is a homotetrameric protein synthesized mainly in liver, choroid plexus, retinal pigment epithelium, and pancreas.Within the CNS, TTR is the only known protein synthesized solely by the choroid plexus. Mutant and wildtype TTR give rise to various forms of amyloid deposition(amyloidosis). Defects in TTR are the cause of amyloidosis transthyretin-related(AMYL-TTR),hyperthyroxinemia dystransthyretinemic euthyroidal(HTDE) and carpal tunnel syndrome type 1(CTS1). In addition, positive immunostaining for TTR has been reported as a sensitive diagnostic marker of choroid plexus tumors.(22103483)
Field of research: Cancer, Immunology, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200
Target: TTR
Purification: Protein A+G purification
Reactivity: Human