PKM2-specific antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: PKM2 pyruvate kinase, muscle
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 58 kDa
Uniprot: P14618
Gene id:
Background: PKM2, also named as OIP3, PK2, PK3, PKM, p58, THBP1, CTHBP and Tumor M2-PK, belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM2 plays a general role in caspase independent cell death of tumor cells. The activity of the M2 isoform (but not the M1 isoform) can be inhibited by tyrosine kinase signalling in tumourcells.The primary pyruvate kinase isoform before tumour development is PK-M1; however, the primary isoform from four independent tumours is PK-M2.(PMID:18337823) PKM2, Pyruvate kinase isozymes M1
M2, has 2 isoforms.The immunogen of this antibody is M2 isoform, also called PKM2. This antibody is specific to PKM2 isoform.
Field of research: Stem Cells, Cancer, Cardiovascular, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF, IP
Dilution: WB: 1:1000-1:4000; IP: 1:200-1:1000; IHC: 1:100-1:400; IF: 1:10-1:100
Target: PKM2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse
![]()
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: PKM2 pyruvate kinase, muscle
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 58 kDa
Uniprot: P14618
Gene id:
Background: PKM2, also named as OIP3, PK2, PK3, PKM, p58, THBP1, CTHBP and Tumor M2-PK, belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM2 plays a general role in caspase independent cell death of tumor cells. The activity of the M2 isoform (but not the M1 isoform) can be inhibited by tyrosine kinase signalling in tumourcells.The primary pyruvate kinase isoform before tumour development is PK-M1; however, the primary isoform from four independent tumours is PK-M2.(PMID:18337823) PKM2, Pyruvate kinase isozymes M1
M2, has 2 isoforms.The immunogen of this antibody is M2 isoform, also called PKM2. This antibody is specific to PKM2 isoform.
Field of research: Stem Cells, Cancer, Cardiovascular, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF, IP
Dilution: WB: 1:1000-1:4000; IP: 1:200-1:1000; IHC: 1:100-1:400; IF: 1:10-1:100
Target: PKM2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse