phospho-TDP43 (409/410) antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: TAR DNA binding protein
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 48 kDa
Uniprot: Q13148
Gene id: 23435
Background: TDP-43 is a 414 amino acid (aa) nuclear DNA and RNA-binding protein which regulates transcription and splicing. TDP-43 is aberrantly expressed in most forms of amylotrophic lateral sclerosis and frontotemporal lobar degeneration. In these cases it is absent from the nucleus and accumulates, along with a truncated 25kDa form, in ubiquitin-containing inclusion bodies. In pathological tissues, TDP-43 is highly phosphorylated and Ser409
410 is the main phosphorylation site. Among the TDP-43 protein fragments, the 25kDa fragment is also highly phosphorylated and widely believed to be pathogenic. This antibody is a rabbit polyclonal antibody recognizing TDP-43 only when phosphorylated at 409
410. This antibody detects phosphorylated forms of TDP-43 as well as the cleavage product of 25 kDa.
Field of research: Neuroscience, Metabolism, Epigenetics
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: phospho-TDP43 (409
410)
Purification: Immunogen affinity purified
Reactivity: Human, Mouse
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: TAR DNA binding protein
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 48 kDa
Uniprot: Q13148
Gene id: 23435
Background: TDP-43 is a 414 amino acid (aa) nuclear DNA and RNA-binding protein which regulates transcription and splicing. TDP-43 is aberrantly expressed in most forms of amylotrophic lateral sclerosis and frontotemporal lobar degeneration. In these cases it is absent from the nucleus and accumulates, along with a truncated 25kDa form, in ubiquitin-containing inclusion bodies. In pathological tissues, TDP-43 is highly phosphorylated and Ser409
410 is the main phosphorylation site. Among the TDP-43 protein fragments, the 25kDa fragment is also highly phosphorylated and widely believed to be pathogenic. This antibody is a rabbit polyclonal antibody recognizing TDP-43 only when phosphorylated at 409
410. This antibody detects phosphorylated forms of TDP-43 as well as the cleavage product of 25 kDa.
Field of research: Neuroscience, Metabolism, Epigenetics
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: phospho-TDP43 (409
410)
Purification: Immunogen affinity purified
Reactivity: Human, Mouse