NFE2L2 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: nuclear factor(erythroid-derived 2)-like 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 70-100 kDa
Uniprot: Q16236
Gene id: 4780
Background: NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response(ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress(PMID:14567983).In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance(PMID:20534738). Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC.
Field of research: Epigenetics, Cancer, Metabolism, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IP, WB, IHC, FC
Dilution: WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:50-1:500
Target: NFE2L2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat, Zebrafish
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: nuclear factor(erythroid-derived 2)-like 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 70-100 kDa
Uniprot: Q16236
Gene id: 4780
Background: NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response(ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress(PMID:14567983).In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance(PMID:20534738). Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC.
Field of research: Epigenetics, Cancer, Metabolism, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IP, WB, IHC, FC
Dilution: WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:50-1:500
Target: NFE2L2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat, Zebrafish