NGEF antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: neuronal guanine nucleotide exchange factor
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 75 kDa
Uniprot: Q8N5V2
Gene id: 25791
Background: Acts as a guanine nucleotide exchange factor(GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension(By similarity).
Field of research: Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IP, IHC
Dilution: WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:50-1:500
Target: NGEF
Purification: Immunogen affinity purified
Reactivity: Human, Mouse
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: neuronal guanine nucleotide exchange factor
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 75 kDa
Uniprot: Q8N5V2
Gene id: 25791
Background: Acts as a guanine nucleotide exchange factor(GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension(By similarity).
Field of research: Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IP, IHC
Dilution: WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:50-1:500
Target: NGEF
Purification: Immunogen affinity purified
Reactivity: Human, Mouse