NFKBIZ antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 64 kDa
Uniprot: Q9BYH8
Gene id: 64332
Background: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1
p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1
p50 has transcriptional activation activity and, together with NFKB1
p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR
IL-1 receptor signaling. May promote apoptosis(By similarity).
Field of research: Epigenetics, Immunology, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, WB
Dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Target: NFKBIZ
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 64 kDa
Uniprot: Q9BYH8
Gene id: 64332
Background: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1
p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1
p50 has transcriptional activation activity and, together with NFKB1
p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR
IL-1 receptor signaling. May promote apoptosis(By similarity).
Field of research: Epigenetics, Immunology, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, WB
Dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Target: NFKBIZ
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat