NEIL3 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: nei endonuclease VIII-like 3(E. coli)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 62-68 kDa
Uniprot: Q8TAT5
Gene id: 55247
Background: DNA glycosylase which prefers single-stranded DNA(ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA(dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin(Sp) and guanidinohydantoin(Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem
progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: NEIL3
Purification: Immunogen affinity purified
Reactivity: Human, Mouse
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: nei endonuclease VIII-like 3(E. coli)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 62-68 kDa
Uniprot: Q8TAT5
Gene id: 55247
Background: DNA glycosylase which prefers single-stranded DNA(ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA(dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin(Sp) and guanidinohydantoin(Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem
progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: NEIL3
Purification: Immunogen affinity purified
Reactivity: Human, Mouse