MICAL2 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: microtubule associated monoxygenase, calponin and LIM domain containing 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 95, 112 kDa
Uniprot: O94851
Gene id: 9645
Background: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1
MRTF-A presence in the nucleus and promote SRF:MKL1
MRTF-A-dependent gene transcription. Does not activate SRF:MKL1
MRTF-A through RhoA.
Field of research: Metabolism, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, IF
Dilution: IHC: 1:20-1:200; IF: 1:20-1:200
Target: MICAL2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: microtubule associated monoxygenase, calponin and LIM domain containing 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 95, 112 kDa
Uniprot: O94851
Gene id: 9645
Background: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1
MRTF-A presence in the nucleus and promote SRF:MKL1
MRTF-A-dependent gene transcription. Does not activate SRF:MKL1
MRTF-A through RhoA.
Field of research: Metabolism, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, IF
Dilution: IHC: 1:20-1:200; IF: 1:20-1:200
Target: MICAL2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat