MBD2 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: methyl-CpG binding domain protein 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 43-45 kDa
Uniprot: Q9UBB5
Gene id: 8932
Background: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: MBD2
Purification: Immunogen affinity purified
Reactivity: Human, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: methyl-CpG binding domain protein 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 43-45 kDa
Uniprot: Q9UBB5
Gene id: 8932
Background: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: MBD2
Purification: Immunogen affinity purified
Reactivity: Human, Rat