MAPKAPK5 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: mitogen-activated protein kinase-activated protein kinase 5
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 54 kDa
Uniprot: Q8IW41
Gene id: 8550
Background: Tumor suppressor serine
threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3
MAPK6, ERK4
MAPK4, HSP27
HSPB1, p53
TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53
TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3
MAPK6 or ERK4
MAPK4: the precise role of the complex formed with ERK3
MAPK6 or ERK4
MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK(ERK3
MAPK6 or ERK4
MAPK4), ERK3
MAPK6(or ERK4
MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3
MAPK6(or ERK4
MAPK4). Mediates phosphorylation of HSP27
HSPB1 in response to PKA
PRKACA stimulation, inducing F-actin rearrangement.
Field of research: Signal Transduction, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IP
Dilution: WB: 1:500-1:2000; IP: 1:200-1:2000
Target: MAPKAPK5
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: mitogen-activated protein kinase-activated protein kinase 5
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 54 kDa
Uniprot: Q8IW41
Gene id: 8550
Background: Tumor suppressor serine
threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3
MAPK6, ERK4
MAPK4, HSP27
HSPB1, p53
TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53
TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3
MAPK6 or ERK4
MAPK4: the precise role of the complex formed with ERK3
MAPK6 or ERK4
MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK(ERK3
MAPK6 or ERK4
MAPK4), ERK3
MAPK6(or ERK4
MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3
MAPK6(or ERK4
MAPK4). Mediates phosphorylation of HSP27
HSPB1 in response to PKA
PRKACA stimulation, inducing F-actin rearrangement.
Field of research: Signal Transduction, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IP
Dilution: WB: 1:500-1:2000; IP: 1:200-1:2000
Target: MAPKAPK5
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat