MAPK10 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: mitogen-activated protein kinase 10
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 45-48 kDa, 54-57 kDa
Uniprot: P53779
Gene id: 5602
Background: Serine
threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase
c-Jun N-terminal kinase(SAP
JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4
MKK4 and MAP2K7
MKK7 phosphorylate and activate MAPK10
JNK3. In turn, MAPK10
JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein
APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL
BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock(PubMed:22441692).
Field of research: Immunology, Cardiovascular, Metabolism, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IF
Dilution: WB: 1:500-1:2000; IF: 1:20-1:200
Target: MAPK10
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
![]()
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: mitogen-activated protein kinase 10
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 45-48 kDa, 54-57 kDa
Uniprot: P53779
Gene id: 5602
Background: Serine
threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase
c-Jun N-terminal kinase(SAP
JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4
MKK4 and MAP2K7
MKK7 phosphorylate and activate MAPK10
JNK3. In turn, MAPK10
JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein
APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL
BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock(PubMed:22441692).
Field of research: Immunology, Cardiovascular, Metabolism, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IF
Dilution: WB: 1:500-1:2000; IF: 1:20-1:200
Target: MAPK10
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat