KEAP1 antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 9E2
Isotype: IgG2a
Immunogen: kelch-like ECH-associated protein 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 55-70 kDa
Uniprot: Q14145
Gene id: 9817
Background: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2
NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2
NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Field of research: Cancer, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, WB, IF
Dilution: WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100
Target: KEAP1
Purification: Protein A+G purification
Reactivity: Human, Mouse, Rat
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Clonality: Monoclonal
Clone: 9E2
Isotype: IgG2a
Immunogen: kelch-like ECH-associated protein 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 55-70 kDa
Uniprot: Q14145
Gene id: 9817
Background: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2
NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2
NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Field of research: Cancer, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, WB, IF
Dilution: WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100
Target: KEAP1
Purification: Protein A+G purification
Reactivity: Human, Mouse, Rat