IRF1 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: interferon regulatory factor 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 45-50 kDa
Uniprot: P10914
Gene id: 3659
Background: Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element(ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha
beta, DDX58
RIG-I, TNFSF10
TRAIL, OAS1
2, PIAS1
GBP, EIF2AK2
PKR and RSAD2
viperin; antibacterial response, such as NOS2
INOS; anti-proliferative response, such as p53
TP53, LOX and CDKN1A; apoptosis, such as BBC3
PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A
B and IL15, PTGS2
COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ
POLH; MHC class I expression, such as TAP1, PSMB9
LMP2, PSME1
PA28A, PSME2
PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5
survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53
TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53
TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T(Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.
Field of research: Epigenetics, Cancer, Immunology, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100
Target: IRF1
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: interferon regulatory factor 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 45-50 kDa
Uniprot: P10914
Gene id: 3659
Background: Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element(ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha
beta, DDX58
RIG-I, TNFSF10
TRAIL, OAS1
2, PIAS1
GBP, EIF2AK2
PKR and RSAD2
viperin; antibacterial response, such as NOS2
INOS; anti-proliferative response, such as p53
TP53, LOX and CDKN1A; apoptosis, such as BBC3
PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A
B and IL15, PTGS2
COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ
POLH; MHC class I expression, such as TAP1, PSMB9
LMP2, PSME1
PA28A, PSME2
PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5
survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53
TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53
TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T(Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.
Field of research: Epigenetics, Cancer, Immunology, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100
Target: IRF1
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat