IL17A antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 5E2
Isotype: IgG1
Immunogen: interleukin 17A
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 18 kDa
Uniprot: Q16552
Gene id: 3605
Background: IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2(PTGS2
COX-2), as well as enhance the production of nitric oxide(NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.
Field of research: Immunology, Cardiovascular, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, FC
Dilution: WB: 1:500-1:1000
Target: IL17A
Purification: Protein A+G purification
Reactivity: Human
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Clonality: Monoclonal
Clone: 5E2
Isotype: IgG1
Immunogen: interleukin 17A
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 18 kDa
Uniprot: Q16552
Gene id: 3605
Background: IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2(PTGS2
COX-2), as well as enhance the production of nitric oxide(NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.
Field of research: Immunology, Cardiovascular, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, FC
Dilution: WB: 1:500-1:1000
Target: IL17A
Purification: Protein A+G purification
Reactivity: Human