IL12B antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: interleukin 12B
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 37 kDa
Uniprot: P29460
Gene id: 3593
Background: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK
lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Field of research: Immunology, Cardiovascular, Developmental biology, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: IL12B
Purification: Immunogen affinity purified
Reactivity: Human
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: interleukin 12B
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 37 kDa
Uniprot: P29460
Gene id: 3593
Background: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK
lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Field of research: Immunology, Cardiovascular, Developmental biology, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: IL12B
Purification: Immunogen affinity purified
Reactivity: Human