HIF1A antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: hypoxia inducible factor 1, alpha subunit(basic helix-loop-helix transcription factor)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 120 kDa
Uniprot: Q16665
Gene id: 3091
Background: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element(HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
Field of research: Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience, Stem Cells
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, IF, FC, WB
Dilution: WB: 1:200-1:1000; IHC: 1:50-1:200; IF: 1:10-1:100
Target: HIF1A
Purification: Immunogen affinity purified
Reactivity: Human
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: hypoxia inducible factor 1, alpha subunit(basic helix-loop-helix transcription factor)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 120 kDa
Uniprot: Q16665
Gene id: 3091
Background: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element(HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
Field of research: Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience, Stem Cells
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, IF, FC, WB
Dilution: WB: 1:200-1:1000; IHC: 1:50-1:200; IF: 1:10-1:100
Target: HIF1A
Purification: Immunogen affinity purified
Reactivity: Human