GRK6 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: G protein-coupled receptor kinase 6
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 66 kDa
Uniprot: P43250
Gene id: 2870
Background: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis(By similarity). Phosphorylates rhodopsin(RHO)(in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling(in vitro).
Field of research: Neuroscience, Cardiovascular, Metabolism, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: GRK6
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: G protein-coupled receptor kinase 6
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 66 kDa
Uniprot: P43250
Gene id: 2870
Background: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis(By similarity). Phosphorylates rhodopsin(RHO)(in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling(in vitro).
Field of research: Neuroscience, Cardiovascular, Metabolism, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: GRK6
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat