GRK5 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: G protein-coupled receptor kinase 5
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 68 kDa
Uniprot: P34947
Gene id: 2869
Background: Serine
threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors(GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors(more specifically Gi-coupled M2
M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein
ST13, TP53
p53, HDAC5, and arrestin-1
ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1
MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2(MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53
p53, a crucial tumor suppressor, inhibits TP53
p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin(RHO)(in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling(in vitro).
Field of research: Neuroscience, Cardiovascular, Metabolism, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: GRK5
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: G protein-coupled receptor kinase 5
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 68 kDa
Uniprot: P34947
Gene id: 2869
Background: Serine
threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors(GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors(more specifically Gi-coupled M2
M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein
ST13, TP53
p53, HDAC5, and arrestin-1
ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1
MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2(MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53
p53, a crucial tumor suppressor, inhibits TP53
p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin(RHO)(in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling(in vitro).
Field of research: Neuroscience, Cardiovascular, Metabolism, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: GRK5
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat