GRB14 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: growth factor receptor-bound protein 14
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 61 kDa
Uniprot: Q14449
Gene id: 2888
Background: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor(INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB
AKT1 phosphorylation and transduction of the insulin signal.
Field of research: Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, WB
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200
Target: GRB14
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: growth factor receptor-bound protein 14
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 61 kDa
Uniprot: Q14449
Gene id: 2888
Background: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor(INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB
AKT1 phosphorylation and transduction of the insulin signal.
Field of research: Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, WB
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200
Target: GRB14
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat