FAS antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 4B6
Isotype: IgG2a
Immunogen: Fas(TNF receptor superfamily, member 6)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 38-45 kDa
Uniprot: P25445
Gene id: 355
Background: Fas(CD95
APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor(TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex(DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form(40-55 kDa) of Fas is due to glycosylation.
Field of research: Cancer, Immunology, Cardiovascular, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, FC,IHC
Dilution: WB: 1:1000-1:8000; IHC: 1:50-1:500
Target: FAS
Purification: Protein A+G purification
Reactivity: Human, Mouse
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Clonality: Monoclonal
Clone: 4B6
Isotype: IgG2a
Immunogen: Fas(TNF receptor superfamily, member 6)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 38-45 kDa
Uniprot: P25445
Gene id: 355
Background: Fas(CD95
APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor(TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex(DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form(40-55 kDa) of Fas is due to glycosylation.
Field of research: Cancer, Immunology, Cardiovascular, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, FC,IHC
Dilution: WB: 1:1000-1:8000; IHC: 1:50-1:500
Target: FAS
Purification: Protein A+G purification
Reactivity: Human, Mouse