EPHB4 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: EPH receptor B4
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 110 kDa
Uniprot: P54760
Gene id: 2050
Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand
functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
Field of research: Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology, Neuroscience
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, FC, WB
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200
Target: EPHB4
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: EPH receptor B4
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 110 kDa
Uniprot: P54760
Gene id: 2050
Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand
functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
Field of research: Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology, Neuroscience
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, FC, WB
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200
Target: EPHB4
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat