DKK1 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: dickkopf homolog 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 30-35 kDa
Uniprot: O94907
Gene id: 22943
Background: Antagonizes canonical Wnt signaling by inhibiting LRP5
6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5
6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Field of research: Signal Transduction, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IF, IHC
Dilution: WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100
Target: DKK1
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: dickkopf homolog 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 30-35 kDa
Uniprot: O94907
Gene id: 22943
Background: Antagonizes canonical Wnt signaling by inhibiting LRP5
6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5
6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Field of research: Signal Transduction, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IF, IHC
Dilution: WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100
Target: DKK1
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat