DIABLO antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: diablo homolog(Drosophila)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 20 kDa
Uniprot: Q9NR28
Gene id: 56616
Background: Promotes apoptosis by activating caspases in the cytochrome c
Apaf-1
caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins(IAP). Inhibits the activity of BIRC6
bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP
BIRC4 by promoting XIAP
BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP
BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP
BIRC4 abundance.This antibody recognizes all the three isoforms of DIABLO.
Field of research: Cancer
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IP
Dilution: WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200
Target: DIABLO
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: diablo homolog(Drosophila)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 20 kDa
Uniprot: Q9NR28
Gene id: 56616
Background: Promotes apoptosis by activating caspases in the cytochrome c
Apaf-1
caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins(IAP). Inhibits the activity of BIRC6
bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP
BIRC4 by promoting XIAP
BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP
BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP
BIRC4 abundance.This antibody recognizes all the three isoforms of DIABLO.
Field of research: Cancer
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IP
Dilution: WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200
Target: DIABLO
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat