CCND1 antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 8E8
Isotype: IgG2a
Immunogen: cyclin D1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 36 kDa
Uniprot: P24385
Gene id: 595
Background: CCND1(cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1
S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma(MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.
Field of research: Metabolism, Immunology, Cell Division and Proliferation, Cancer
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:2000-1:10000
Target: CCND1
Purification: Protein A+G purification
Reactivity: Human, Mouse
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Clonality: Monoclonal
Clone: 8E8
Isotype: IgG2a
Immunogen: cyclin D1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 36 kDa
Uniprot: P24385
Gene id: 595
Background: CCND1(cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1
S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma(MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.
Field of research: Metabolism, Immunology, Cell Division and Proliferation, Cancer
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:2000-1:10000
Target: CCND1
Purification: Protein A+G purification
Reactivity: Human, Mouse