CTNNA1 antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 0A11
Isotype: IgG1
Immunogen: catenin(cadherin-associated protein), alpha 1, 102kDa
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 95-100 kDa
Uniprot: P35221
Gene id: 1495
Background: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E-and N-cadherins. Originally believed to be a stable component of E-cadherin
catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin
catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2
3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Field of research: cancer, Signal Transduction, stem cells
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:500-1:2000; IHC: 1:50-1:1000
Target: CTNNA1
Purification: Protein A+G purification
Reactivity: Human, Mouse
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Clonality: Monoclonal
Clone: 0A11
Isotype: IgG1
Immunogen: catenin(cadherin-associated protein), alpha 1, 102kDa
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 95-100 kDa
Uniprot: P35221
Gene id: 1495
Background: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E-and N-cadherins. Originally believed to be a stable component of E-cadherin
catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin
catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2
3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Field of research: cancer, Signal Transduction, stem cells
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:500-1:2000; IHC: 1:50-1:1000
Target: CTNNA1
Purification: Protein A+G purification
Reactivity: Human, Mouse