CLSPN antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: claspin homolog(Xenopus laevis)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 240 kDa
Uniprot: Q9HAW4
Gene id: 63967
Background: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex(pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
Field of research:
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IF, IP
Dilution: WB: 1:200-1:1000; IP: 1:500-1:2000; IF: 1:20-1:200
Target: CLSPN
Purification: Immunogen affinity purified
Reactivity: Human
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: claspin homolog(Xenopus laevis)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 240 kDa
Uniprot: Q9HAW4
Gene id: 63967
Background: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex(pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
Field of research:
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IF, IP
Dilution: WB: 1:200-1:1000; IP: 1:500-1:2000; IF: 1:20-1:200
Target: CLSPN
Purification: Immunogen affinity purified
Reactivity: Human