DDIT3 antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 5H7
Isotype: IgG2a
Immunogen: DNA-damage-inducible transcript 3
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 30 kDa
Uniprot: P35638
Gene id: 1649
Background: CHOP, also known as GADD153 or DDIT3, is a highly conserved gene in both the structural and regulatory regions to hamster gene.Imposed by unfolded and malfolded proteins, CHOP is significantly induced by ER stress, deficiency of CHOP prevents cell from ER stress. CHOP is considered a proapoptotic marker of ER stress dependent cell death. CHOP acts as a dominant-negative inhibitor of the transcription factor C
EBP and LAP by forming a heterodimer. It may play an important role in the malignant transformation of nevus to melanoma.
Field of research: Epigenetics, Stem Cells, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:5000
Target: DDIT3
Purification: Protein A+G purification
Reactivity: Human, Mouse, Rat
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Clonality: Monoclonal
Clone: 5H7
Isotype: IgG2a
Immunogen: DNA-damage-inducible transcript 3
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 30 kDa
Uniprot: P35638
Gene id: 1649
Background: CHOP, also known as GADD153 or DDIT3, is a highly conserved gene in both the structural and regulatory regions to hamster gene.Imposed by unfolded and malfolded proteins, CHOP is significantly induced by ER stress, deficiency of CHOP prevents cell from ER stress. CHOP is considered a proapoptotic marker of ER stress dependent cell death. CHOP acts as a dominant-negative inhibitor of the transcription factor C
EBP and LAP by forming a heterodimer. It may play an important role in the malignant transformation of nevus to melanoma.
Field of research: Epigenetics, Stem Cells, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:5000
Target: DDIT3
Purification: Protein A+G purification
Reactivity: Human, Mouse, Rat