MCAM antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 0E4
Isotype: IgG1
Immunogen: melanoma cell adhesion molecule
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 113-120 kDa
Uniprot: P43121
Gene id: 4162
Background: CD146, also known as melanoma cell adhesion molecule(MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein belonging to the immunoglobulin(Ig) superfamily(PMID: 8378324). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells(CECs)(PMID: 19356677).
Field of research: Cardiovascular, Immunology, Cancer, Developmental biology, Stem Cells
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, FC
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200
Target: MCAM
Purification: Protein A+G purification
Reactivity: Human
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Clonality: Monoclonal
Clone: 0E4
Isotype: IgG1
Immunogen: melanoma cell adhesion molecule
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 113-120 kDa
Uniprot: P43121
Gene id: 4162
Background: CD146, also known as melanoma cell adhesion molecule(MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein belonging to the immunoglobulin(Ig) superfamily(PMID: 8378324). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells(CECs)(PMID: 19356677).
Field of research: Cardiovascular, Immunology, Cancer, Developmental biology, Stem Cells
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, FC
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200
Target: MCAM
Purification: Protein A+G purification
Reactivity: Human