BRD8 antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 4B2
Isotype: IgG1
Immunogen: bromodomain containing 8
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 120 kDa
Uniprot: Q9H0E9
Gene id: 10902
Background: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors(NR). Isoform 2 stimulates transcriptional activation by AR
DHTR, ESR1
NR3A1, RXRA
NR2B1 and THRB
ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z
H2AFZ from the nucleosome.
Field of research: Signal Transduction, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500
Target: BRD8
Purification: Protein A+G purification
Reactivity: Human
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Clonality: Monoclonal
Clone: 4B2
Isotype: IgG1
Immunogen: bromodomain containing 8
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 120 kDa
Uniprot: Q9H0E9
Gene id: 10902
Background: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors(NR). Isoform 2 stimulates transcriptional activation by AR
DHTR, ESR1
NR3A1, RXRA
NR2B1 and THRB
ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z
H2AFZ from the nucleosome.
Field of research: Signal Transduction, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500
Target: BRD8
Purification: Protein A+G purification
Reactivity: Human