CTCFL antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 2B10
Isotype: IgG1
Immunogen: CCCTC-binding factor(zinc finger protein)-like
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 75 kDa
Uniprot: Q8NI51
Gene id: 140690
Background: CTCFL, also named BORIS(for brother of the regulator of imprinted sites) is a paralogue of the 11 zinc-finger transcription factor, CTCF. It is predominantly expressed in spermatocytes in the testis, also can be found in tumors and cancer cell lines. It mainly participates in insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. It has a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2
H19 imprinted control region(ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2.
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IF
Dilution: WB: 1:500-1:2000; IF: 1:10-1:100
Target: CTCFL
Purification: Protein A+G purification
Reactivity: Human, Mouse
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Clonality: Monoclonal
Clone: 2B10
Isotype: IgG1
Immunogen: CCCTC-binding factor(zinc finger protein)-like
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 75 kDa
Uniprot: Q8NI51
Gene id: 140690
Background: CTCFL, also named BORIS(for brother of the regulator of imprinted sites) is a paralogue of the 11 zinc-finger transcription factor, CTCF. It is predominantly expressed in spermatocytes in the testis, also can be found in tumors and cancer cell lines. It mainly participates in insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. It has a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2
H19 imprinted control region(ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2.
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IF
Dilution: WB: 1:500-1:2000; IF: 1:10-1:100
Target: CTCFL
Purification: Protein A+G purification
Reactivity: Human, Mouse