BCL2 antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 8A10
Isotype: IgG2a
Immunogen: B-cell CLL
lymphoma 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 26 kDa
Uniprot: P10415
Gene id: 596
Background: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and
or by binding to the apoptosis-activating factor(APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785).
Field of research: Neuroscience, Cancer, Immunology, Cardiovascular
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IP, IHC
Dilution: WB: 1:1000-1:10000; IP: 1:500-1:5000; IHC: 1:100-1:2000
Target: BCL2
Purification: Protein A+G purification
Reactivity: Human
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Clonality: Monoclonal
Clone: 8A10
Isotype: IgG2a
Immunogen: B-cell CLL
lymphoma 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 26 kDa
Uniprot: P10415
Gene id: 596
Background: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and
or by binding to the apoptosis-activating factor(APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785).
Field of research: Neuroscience, Cancer, Immunology, Cardiovascular
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IP, IHC
Dilution: WB: 1:1000-1:10000; IP: 1:500-1:5000; IHC: 1:100-1:2000
Target: BCL2
Purification: Protein A+G purification
Reactivity: Human