BAX antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: BCL2-associated X protein
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 21 kDa
Uniprot: Q07812
Gene id: 581
Background: BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction(PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria(PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis(PMID: 8183579).
Field of research: Neuroscience, Cancer, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IP, FC
Dilution: WB: 1:1000-1:10000; IP: 1:1000-1:10000; IHC: 1:20-1:200
Target: BAX
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat, Rabbit, Sheep
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: BCL2-associated X protein
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 21 kDa
Uniprot: Q07812
Gene id: 581
Background: BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction(PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria(PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis(PMID: 8183579).
Field of research: Neuroscience, Cancer, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IP, FC
Dilution: WB: 1:1000-1:10000; IP: 1:1000-1:10000; IHC: 1:20-1:200
Target: BAX
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat, Rabbit, Sheep